13 PhD positions on Graphene Based Nanostructures and Materials at sites in UK, France, Spain and Greece

Applications are invited for 13 PhD positions working in graphene-based materials, funded by the EU commission Marie Sklodowska-Curie ITN initiative. These include a post at the Institute of Materials in Nantes concerned with atomic scale DFT modelling of pristine and functionalised graphene, as well as posts including TD-DFT simulations at the National Hellenic Research Foundation in Athens, Greece.

The network entitled “Enabling Excellence” offers integral R&D training at PhD level around one of the most active and exciting topics at the forefront of nanoscience and nanotechnology, graphene-based nanostructures and materials, and associated instrumentation development. This is accompanied by a unique and continuous Communication training programme throughout the duration of the project. We are looking for: 13 excellent candidates to pursue research leading to a PhD from 2015 to 2018 in a European network of excellent academic and non-academic (e.g. SME) institutions. The successful candidates will have a background in Chemistry, Physics, Materials Science, Engineering or a related discipline. They will be highly motivated researchers with an excellent academic background, team players ready to actively contribute to the network activities.

The fellowships will provide supervised multidisciplinary cutting-edge research training in fundamental knowledge of graphene-based nano-objects, the development of functionalities and processing into macroscopic advanced materials and devices, accompanied by a broad set of characterization techniques. They offer excellent opportunities for personalized complementary training through extended exchanges to academic and industrial European network partners (in UK, France, Spain and Greece), accompanied by activities to develop business skills (with opportunities for spin-off development at the end of the PhD). A significant component will be training in communication. It is one of the skills which will ‘Enable‘Excellence’ ; whether your ambition is a research career, or one in the management of science in industry, or in the politics of framing international science policy.

The fellowship includes a research contract of 36 months on a full-time basis, with the opportunity to register for a PhD thesis. An attractive gross salary according to Marie Skłodowska-Curie programme standards is offered, including a generous mobility allowance and additional family allowance where applicable.

Full details including application procedures are available at http://eetraining.wordpress.com/

PhD position-Multiview Learning for Sequence Extraction Tasks, Grenoble - Clermont Ferrand, France

Multiview Learning for Sequence Extraction Tasks

Subject:

With the increase of electronically available textual information in different views, new needs for Information Access systems are arising. Many new tasks lie between the classic frameworks of Information Retrieval (IR) and Information Extraction (IE). Machine Learning (ML) is playing a central role in the development of these fields but has been used for the most part for the improvement of existing models. 

The thesis aims at extending the capabilities of statistical IR models to handle more complex information retrieval and extraction tasks. For this, we are interested in the use of probabilistic sequence models for sequence analysis. In particular, we will consider a text generated by two different sources where each of the texts is a sequence of symbols and not as an unordered set. From this perspective, we seek a sequence model that allows to work at a finer level than what is usually done in IR. Each model associated to a source is learned in the way to minimize the disagreement of the sequence to be extracted with the similar extracted sequence by the other model. Under this framework, we aim to deal with several text analysis tasks within a unifying formalism.

Profile:

For this position, we are looking for highly motivated people, with a passion to work in machine learning, information retrieval and the skills to develop algorithms for prediction in real-life applications. We are looking for an inquisitive mind with the curiosity to use a new and challenging technology that requires a rethinking visual processing to achieve a high payoff in terms of speed and efficiency.

We further seek a candidate with the following additional skills:

- Probability and statistics ;

- The ability to analyze, improve and propose new algorithms ;

- Good knowledge of programming languages with a proved experience is a plus.

Application:

The application should include a brief description of research interests and past experience, a CV, degrees and grades, a copy of Master thesis (or a draft thereof), motivation letter (short but pertinent to this call), relevant publications, and other relevant documents. Candidates are encouraged to provide letter(s) of recommendation and contact information to reference persons. Please send your application in one single pdf to 

massih-reza.amini@imag.fr 

eric.gaussier@imag.fr 

gvernat@coffreo.com

The deadline for the application is July 15th, 2014, but we encourage the applicants to contact us as soon as possible. The final decision will be communicated in the beginning of August.

Duration: 3 years (a full time position) Starting date: September, 2014

Supervisors: Massih-Reza Amini (UJF/LIG, France), Eric Gaussier (UJF/LIG, France), Guillaume Vernat (COFFREO, France)

Working Environment:

The PhD candidate will work at AMA team (http://ama.liglab.fr/) of the Laboratoire d'Informatique de Grenoble (LIG) lab, a leading Computer Science in France and COFFREO (https://www.coffreo.com/) a French leading Firm in electronic safe. Grenoble is the capital of the Alps in France, with excellent train connection to Geneva (2h), Paris (3h) and Turin (4h). AMA team is a dynamic group working in Machine Learning and connected scientific domains over 20 researchers (including PhD students) and that covers several aspects of machine learning from theory to applications, including statistical learning, data-mining, and cognitive science.

Benefits:

* Duration 36 months – (3 weeks a month at Grenoble and 1 week a month at Clermont Ferrand)

* Starting date of the contract : September 2014, 

* Salary after taxes: from 21264 € per year,

* Possibility of French courses Help for housing Participation for public transport Scientific Resident card and help for husband/wife visa

__._,_.___

PhD position in DB & KDD at University of Tours, Blois, France

The DB & NLP group of the CS lab. of the University of Tours, 
France, invites applications for a fully-funded 3-year PhD position 
in the area of data warehousing, data mining, analytics and 
exploratory search, starting in September 2014 in the nice city 
of Blois (http://en.blois.fr/) located in the Unesco World Heritage 
area of the "Loire valley". 


The research area is that of interactive exploratory analysis 
of huge amounts of data and research activities will include 
the empirical study, modeling and benchmarking of exploratory 
analyses. Experimental validation will be carried out in the 
context of a regional project aiming at the interactive analysis 
of open data, to study the energy vulnerability of households 
and territories. 


Applicants should have a M.Sc. in computer science and possess 
a very good knowledge of BI (Business Intelligence) related theory
and technics (data warehousing, OLAP, data mining, information 
retrieval), user-centric approaches (recommendation, personalization) 
and development. Experience with open data will be a plus. 
Good proficiency in English is mandatory. French language skills 
are desirable but not mandatory. 


The monthly gross salary is 1685.43 Euro.


Applicants are invited to send a CV, a copy of the official transcript 
of their Master, a copy of their Masterâ?Ts thesis dissertation, publications, 
a cover letter and reference letters, by email, to Patrick Marcel 
(patrick.marcel@univ-tours.fr).

202 PhD Scholarships at EDITE, Paris, France

This page describes how to apply for EDITE scholarships for 2013. The described procedure allows EDITE to register your application and process it.

Demande d'autorisation d'inscription 

First, UPMC must know more about you. Whatever is the scholarship you apply to whether in CNAM, ParisDescartes, Telecom ParisTech, Telecom ParisSud, you must register with UPMC.

•Or you are already known by UPMC (with a 7 digit number) then directly connect to EDITE. If unknown from EDITE, you will have to tell what is your birthday to authenticate. See next session to proceed.
•If you are unknown from UPMC, then register with UPMC website and fill the demande d'autorisation d'inscription (in French). Register as soon as possible since it usually takes 2 or 3 days before EDITE can extract your registration from UPMC databases.
The demande d'autorisation d'inscription (in French) is a series of forms to fill (see how to here).

Applications to one or more PhD

Connect to EDITE extranet, authenticate (details here) and choose Apply to some scholarships. Choose up to 3 PhD proposals, sort them by decreasing preference and don't forget to save your choices.

On the home page, upload all the documents (PDF only) to support your application: diploma, transcript, recommendation letter(s), etc.

Contact the author of the PhD proposals you apply to. The author, if convinced of the interest of your application, will select it and propose it to a "thematic jury". This jury may convoke you for further examination. Thematic jurys examine the applications and propose a sorted selection of them to the final jury.

Calendar
Applications are open from April 25 to May 22. Thematic jurys will be over by June 24. The final jury will be held on June 25. Results are a list of laureates and a complementary list in case of laureates' dismissals. These two lists will be published before June 29 on this web site. Laureates will receive a personal mail from the director of EDITE.

If you are not a laureate, see with proponents whether other funding resources are available.

http://edite-de-paris.fr/spip/spip.php?article264

http://edite-de-paris.fr/spip/spip.php?page=phdproposals

Company sponsored PhD Program, Renault, France

Scholarship Summary: A Company sponsored PhD Program in Renault, France is available in the DELTA department. The thesis CIFRE is sponsored by Renault.

Proposal for PhD CIFRE Renault
The Department of Electronics and Automotive Advanced Technology (DELTA), Renault offers CIFRE entitled "Study of electrical insulation systems used in motor vehicles Electrical taking into account their specific environment, to ensure the desired life of the electric motor for future generation.

Background:
The current level of tension and its probable increase in the near future, the use of devices power electronics and the specific constraints they generate (as a voltage, steep edges, high frequencies, etc..), not to mention the operating conditions specific to the application (profiles mission thermal cycles, vibratory stress, etc) make the study of Electrical Insulation System (SIE) motors for electric vehicles (VE) a new field of investigation. Indeed, to ensure the duration Life sought, it is vital to understand the mechanisms of degradation of the dielectric insulation of cables, motor winding and power components. Among the risks, we must consider include:
- Breakdown between turns (same phase or different phases) and turns-frame;
- Failure of impedance of distribution lines accompanied by a sharp surge in response to reflections of Electromagnetic wave;
- Non-negligible parasitic capacitances and forehead steep causing a power surge at the entrance of the winding and intense use of the electrical insulation;
- Inhomogeneous distribution of tension in the coil.

Problem:
The whole question is at what level of exposure to risk of failure is the application. By this I mean, the voltage level is it - given a few peculiar "Inverter - can trigger mechanisms of insulation breakdown, discharge partial (DP) and corona discharge? The answer to that question the whole strategy of choice and design of electrical systems that will be used. As part of this work, we try to answer this question. She will consider innovative methods of detecting these phenomena, developed in a different context (aerospace, defense, rail) and seem particularly interesting (radio frequency detection). After studies at the Laboratory, will seek to deploy detection methods on an engine test bench consists of a Renault engine and its electronic
power.

Diploma: Engineer and / or bac + 5 Master 2 research

Preferred areas of expertise: Physics of plasmas, electromagnetism, electrical engineering, signal processing, electronics.

Contact:
Francis Fresent
UET Electro-Physics / DELTA
Renault S.A.S. - TCR RUC T62
1 avenue du Golf
78288 Guyancourt
francois.fresnet @ renault.com

32 PhD Positions in INRIA, France

Thirty-two PhD positions offered

Would you like to carry out rewarding research work in computer science and applied mathematics? Are you a young and talented scientist? INRIA can offer you a position in on one of its research teams to work on your PhD thesis. In 2011, 32 PhD positions are available within the Institute's priority research fields.

Number of jobs, which match your criteria: 42
Title	Position type	Location	Research theme	Project
ALF Reconciling dynamic code generation with static predictability guarantees	PhD Student	Rennes	Networks, systems and services, distributed computing	ALF
BUNRAKU - VR4I Proposition de nouvelles techniques d'interaction 3D et de navigation 3D préservant l'immersion de l'utilisateur	PhD Student	Rennes	Perception, cognition, interaction	BUNKARU
ESPRESSO Génération de code concurrente multi¬tâches déterministe à partir de spécifications polychrones	PhD Student	Rennes	Algorithmics, programmation, software and architecture	ESPRESSO
ESPRESSO Ingénierie de modèles pour la vérification modulaire d'architectures GALS	PhD Student	Rennes	Algorithmics, programmation, software and architecture	ESPRESSO
Dionysos - Modèles probabilistes pour les systèmes distribués	PhD Student	Rennes	Networks, systems and services, distributed computing	DIONYSOS
DIONYSOS_Etudes analytiques de modèles fluides pour réseaux haut débit	PhD Student	Rennes	Applied Mathematics, computation and simulation	DIONYSOS
MYRIADS-Environnement décentralisé pour les nouveaux modèles alternatifs de programmation de l'Internet des services	PhD Student	Rennes	Networks, systems and services, distributed computing	MYRIADS
SYMBIOSE-Discovery of enzymatic functions in the framework of formal languages	PhD Student	Rennes	Computation sciences for biology, medicine and the environnement	SYMBIOSE
TRISKELL-Dynamic Software Product Lines based on Service-Oriented Architectures	PhD Student	Rennes	Networks, systems and services, distributed computing	TRISKELL
TRISKELL-Formal Foundations to Verify DSML Compilers	PhD Student	Rennes	Networks, systems and services, distributed computing	TRISKELL
TRISKELL-Formal Foundations to Verify DSML Compilers	PhD Student	Rennes	Networks, systems and services, distributed computing	TRISKELL
TRISKELL-Learning the specification of black box software services	PhD Student	Rennes	Networks, systems and services, distributed computing	TRISKELL
TRISKELL-Synthesis of service-oriented architectures by model transformation	PhD Student	Rennes	Networks, systems and services, distributed computing	TRISKELL
TRISKELL-Verifying Web Services Composition	PhD Student	Rennes	Networks, systems and services, distributed computing	TRISKELL
VISAGES-Dimensionality reduction and statistical learning for computational modelling of natural evolution of brain pathologies	PhD Student	Rennes	Computation sciences for biology, medicine and the environnement	VISAGES
LAGADIC - Compensation du mouvement de tissus organiques par asservissement visuel échographique	PhD Student	Rennes	Perception, cognition, interaction	LAGADIC
METISS- Modélisation statistique du langage musical pour la recherche d'information dans les contenus musicaux	PhD Student	Rennes	Networks, systems and services, distributed computing	METISS
SYMBIOSE Learning the grammar of genomic sequences	PhD Student	Rennes	Computation sciences for biology, medicine and the environnement	SYMBIOSE
SYMBIOSE Modélisation par contraintes pour le contrôle génomique et physiologique de l’adaptation des algues brunes à la salinité de l’eau	PhD Student	Rennes	Computation sciences for biology, medicine and the environnement	SYMBIOSE
SYMBIOSE Modelling Protein Structure	PhD Student	Rennes	Computation sciences for biology, medicine and the environnement	S

PhD scholarships in Genomics, France

A PhD scholarship in Genomics has been announced for the academic year 2011. The PhD scholarship is in association with the Institute of Nuclear Sciences, France. The research area for this PhD scholarship is Biochemistry/ Life sciences.

Description:
The PhD student will make use of the extensive data sets to identify gene and protein interactions that might be of importance for the development and progression of the disease. Potential interactions and mechanisms of regulation will be validated by the student using a variety of laboratory techniques such as analysis of expression and epigenetic modifications, promoter activity assays, transcription factor binding sites, co-immunoprecipitations in in vitro model systems (cell culture) as well as in tissue samples. For validated targets, blood/plasma based assays for early detection, tumour classification, risk assessment and treatment decisions will be developed.

Location:
Institut de Génomique
Centre national de génotypage
Laboratoire de recherche translationnelle
Starting date:
Centre : Fontenay-aux-roses

Contact person:
Jorg TOST
CEA / DSV/IG/CNG/LRTR:
CEA -Institut de Génomique
Centre National de Génotypage
Laboratoire d'Epigénétique
2 rue Gaston Crémieux
Batiment G2
CP5721
91057 Evry Cedex
France
Email : tost@cng.fr
Phone: 01 60 87 84 23

For more details about the PhD scholarships in Genomics, France please visit the PhD scholarships link.
http://www.cng.fr/fr/teams/epigen/index.html

Note: The applcation deadline to the PhD scholarships in Genomics, France is 08 March, 2011.

Post doc in medial science, France

Post-doctoral fellowship

Bergonié Cancer Institute is an internationally recognized research institution with a dynamic research, a good clinical environment, an extensive infrastructural and core facility support. Scientific research at the Bergonié Cancer Institute covers the full spectrum of cancer research, from basic studies on tumour biology to clinical trials and epidemiology. The basic scientists are integrated into an INSERM unit (U916) whose goals are to identify and validate new gene signatures and drug targets. To this end, three approaches are developed: Identification of molecular targets, Preclinical and Clinical validation. Individual scientists and clinicians work together in groups mostly based on tumour type: sarcoma, breast cancer, colorectal cancer and lymphoma.

Scientific description: The aim of the research project is to investigate the role of ionic channels, intracellular calcium and pH in the regulation of the death receptors-mediated signaling pathways by using a wide range of technologies including patch-clamp electrophysiology, calcium imaging, molecular and cellular physiology and biochemical techniques. Biological materials used in this study will include lymphocytes issued from blood samples of healthy donors and patients with lymphocyte malignancies, and cell lines.

Position: 24 months postdoctoral fellowship (starting January, 2011) funded by the National Cancer Institute (INCa). The wages will be around 2000 €/month. This position is seeking candidates interested in pursuing an academic research career.

Profile: Ideal candidates must have a recent Ph.D. degree and/or M.D. with substantial research experience in biochemistry, electrophysiology, molecular, cellular or cancer biology, or a related discipline. Previous work in the field of cancer biology is preferred. A good expertise in the area of apoptosis/cell death or immunology will be appreciated.

Successful candidate will lead an innovative and integrated project at the interface of electrophysiology and biology. Opportunities to be part of several ongoing collaborations will enhance the opportunity for publications.

Location: University of Bordeaux, Bergonié Cancer Institute, Bordeaux, France. Bordeaux, capital of Aquitania, combines high-level research laboratories and a unique quality of life in a renowned cultural setting.

Requirements:

- Technical independence with cell culturing, transfections, Western blotting, patch clamp electrophysiology, calcium imaging, and standard molecular and cell biology techniques.

- Meticulous at planning, executing, and organizing experiments

- Candidate must also be able to take initiative, to work independently and in a collaborative setting

- A good publication record in recognized peer-reviewed journals

Application:

Candidates should send a cover letter summarizing qualifications and experience, updated curriculum vitae including publications list and three academic reference letters with names/addresses/e-mail contacts to:

Dr. Pierre VACHER (e-mail: Pierre.Vacher@inserm.fr).

INSERM U916, Institut Bergonié, 229 cours de l’Argonne 33076 Bordeaux Cedex, France

Eiffel Scholarships 2011, France

Eiffel scholarships

The French Ministry of Foreign and European Affairs launched the Eiffel excellence scholarship programme in January 1999 to support French centres of higher education in their international outreach initiatives, in a context of mounting competition among developed countries, to attract elite overseas students on master's, engineering and PhD courses.

2011/2012 Session timetable

•Application forms put online: 27 September 2010
•Deadline for reception of applications by Égide: 7 January 2011
•Announcement of results: week of 21 March 2011

http://www.egide.asso.fr/jahia/Jahia/appels/eiffel

French Government Scholarships (BGF) 2011, France

Scholarship to France: BGF

French Government Scholarship (BGF) in 2011 has been opened!

About BGF 2011:

The French government through the French Embassy in Jakarta has provided scholarships to citizens of Indonesia for more than 30 years. In order to develop human resources in Indonesia, the French Embassy will provide scholarships for 2010.

The scholarships are given to civil servants, lecturers, students (especially those involved in the cooperation program between France and Indonesia) to follow the 2 types of educational programs:

Masters (full scholarship)
Doctorate (full scholarship - 18 months)

The jury will give priority to those who had to identify either a masters or doctorate program and who has had a positive response / recommendations from a professor of French or letter of acceptance.
CampusFrance Indonesia can help you to find courses that interest you.

Applications must be submitted no later than 31 March 2011!

http://indonesia.campusfrance.org/id/pages-transverses/membiayai-studi-anda/beasiswa-ke-prancis-bgf-146.html

Post doc position in Grenoble, France

Grenoble Institut des Neurosciences – Centre de Recherche Inserm n°U 836-UJF-CEA-CHU

Directeur : Claude Feuerstein

-----------------------

Le Secrétariat – Caroline Weber

Tél. : 04 56 52 06 56

Fax : 04 56 52 06 57

Email caroline.weber@ujf-grenoble.fr

Adresse Géographique :

Grenoble Institut des Neurosciences

Centre de Recherche Inserm U.836 – UJF-CEA-CHU

Bâtiment Edmond J. Safra

Chemin Fortuné Ferrini

38700 La Tronche - France

Adresse Postale :

Grenoble Institut des Neurosciences

Centre de Recherche Inserm U.836 – UJF-CEA-CHU

Bâtiment Edmond J. Safra

Université Joseph Fourier

Site Santé à La Tronche

BP 170

38042 GRENOBLE Cedex 9 – France

POST-DOC POSITION FOR 2 YEARS

The candidate should be well trained in calcium imaging on brain slice or in vivo.

Proposition

A two years post-doctoral position will be available in Grenoble–institute of neurosciences

(France) as for january 2011 to work on a project coordinated by Antoine Depaulis

(antoine.depaulis@ujf-grenoble.fr) untitled : “Do cortical astrocytes play a role in the

occurrence of absence epilepsy ? A calcium imaging and two photon microscopy approach

in a genetic rat model”.

The objective of the project is to determine whether absence epilepsy is associated with

the development of an anomaly of the cortical glial network and/or a dysfunction of

neuron-glial relationships during cortical maturation.

The program is developed in collaboration with 4 teams including neurobiologists

specialized in epilepsy and calcium imaging (I Guillemain and M Albrieux) and physicists

specialized in two-photon imaging (JC Vial and B Van der Sanden).

The candidate will focus on experiments that will determine the functional aspects of the

glial network and its relationship with the neural network by measuring spontaneous and

induced calcium movements and cell synchrony on cortical slices of epileptic rat pups and

controls of the same age. The implication of neuro- and glio-transmission in the observed

events will be studied using specific pharmacological tools.

Key words : epileptogenesis, glial network, calcium imaging, neuron-glia relationship,

brain slices, in vivo recording.

Techniques

Calcium imaging in brain slice or in vivo. Confocal or two-photon microscopy

Conditions

Start date : january 2011

Duration : 2 years

Funding : ANR grant (around 26000 euros /year)

Contact

Applications, including a CV, list of publications and names for two references should be

sent by e-mail to: Isabelle Guillemain : isabelle.guillemain@ujf-grenoble.fr and Mireille

Albrieux : mireille.albrieux@ujf-grenoble.fr

Post doc in Bordeaux, France

Position profile : Post-doctoral researcher (m/f)

Duration : 2 years contract

Structure : IMN BORDEAUX, FRANCE

level: PhD

title: Neurophysiology fellowship

Range of salary : 1800 - 2200€ per month (net) (according to experience)

Host Organization :

The « Institut des Maladies Neurodégénératives » (IMN – Institute of Neurodegenerative Disorders) is a research unit under the guardianship of the CNRS and the University Victor Segalen-Bordeaux 2. It supports close links with the University Hospital of Bordeaux. The laboratory, featuring 95 persons, is an integral part of the Neurocampus, the Bordeaux Excellence center for Neuroscience. The laboratory is organized into 7 independent scientific teams.

MISSION :

The post-doc will be in charge, under the supervision of the project leader and in close collaboration with the other project members, of a project aiming at restoring motor performances in the Parkinson’s disease gold standard, the MPTP-treated non-human primate, through the development of brain-machine interface.

This project is supported by European contract (NEUWALK) aiming at characterizing the electrophysiologial and cinematic parameters of a “normal” state, at developing the movement analysis methodology, at performing the surgical implantation of a “smart” stimulator invented and developed by our partners in the European network on the parkinsonian monkeys and at quantifying the behavioral consequences.

ACTVITIES :

Ø To develop protocols and adapt the experimental conditions in order to answer to the project goals

Ø To jointly run electrophysiological investigations (chronic EMG recordings, tridimensional kinematics, cortical and subcortical multi-single unit telemetric recordings) in a pathophysiological context (macaque model of Parkinson’s disease)

Ø To share and exploit the data with the European partners in order to better define and improve the characteristics of the spinal stimulator.

EXPERIENCE :

Ø Strong knowledge in movement physiology, Basal Ganglia physiology, and cellular biology.

Ø Proven practice in electrophysiology – Master the conceptual framework

Ø Fluent in English

ABILITY :

The following attributes will be well-regarded: ability to communicate with people at all levels, strong time organization proficiency, aptitude to work both unsupervised and as a part of a team, competency in data processing and in using analysis softwares (e.g. Mathlab).

Contact :

To apply, send a e-mail at Erwan Bezard (Erwan.bezard@u-bordeaux2.fr) and Christian Gross (christian.gross@u-bordeaux2.fr), with a cover letter, a CV, the list of publications and the summary of the PhD dissertation

------------------------------------------------------------

Flat price in Bordeaux? see some examples here, here or here.
Pictures of Bordeaux

Post-doc Chemistry, In Nice, France

A two-year postdoctoral position is available in the Ion Channel Genetics team at IPMC -

TIANP (UMR CNRS 6097) located at the Science faculty in Parc Varlose in Nice, south of

France ( http://www.unice.fr/tianp).

Subject: TASK K+ channel contribution in breathing adaptation to O2, CO2 and

pH changes

Context of the study

The chemosensitivity is an essential property of the respiratory system to permanently adapt

its activity to the needs of the body. Specialized sensors at the periphery (mainly carotid

bodies) and at the central level (specialized nuclei in the brainstem) are involved in

monitoring arterial blood CO2 and O2 pressures as well as pH. Defects of central

chemoreception are implicated in respiratory pathologies such as sleep apnea syndromes,

periodic breathing in high altitude and drug- or anesthesia-induced respiratory depression.

The congenital central hypoventilation syndrome is a severe hereditary form of central

breathing chemosensitivity in human. The brainstem topology of respiratory nuclei is

relatively well known. Yet, we don't precisely know what are the neurons directly involved in

chemosensitivity and even less the exact molecular identities of the chemoreceptors.

Background K+ channels (K2P) of the TASK family display functional characteristics

including pH and reactive oxygen species (ROS) sensitivities that make them good CO2 and

O2 sensors candidates.

In a recently published work, we have identified TASK2 as the molecular O2 sensor in

retrotrapezoid nucleus (RTN) and proposed that its activation by hypoxia generated ROS is

the mechanism by which central hypoxia-induced ventilatory depression takes place

(Gestreau et al 2010).

Objectives

The project is aimed at the characterization of the molecular mechanisms regulating the CO2

and O2 sensing in the brainstem and involved in the adaptation of breathing to the blood gases

relying on the unique model of TASK mutant mice.

We have produced mice invalidated for the three TASK channel genes task1 (kcnk3), task2

(kcnk5) and task3 (kcnk9) as well as double knockout task1-3 and task2-3. The postdoctoral

fellow will develop patch-clamp studies on brainstem slices from these mouse models.

Therefore, a good experience in electrophysiology, and possibly in electrophysiology on

slices would be greatly appreciated.

Post starting January 2011

Duration 24 months

Contact Jacques Barhanin (jacques.barhanin@ unice.fr).

TIANP UMR6097

Faculté des Sciences

Bâtiment Sciences Naturelles

Parc Valrose

06105 Nice, France

Gestreau, C., D. Heitzmann, J. Thomas, V. Dubreuil, S. Bandulik, M. Reichold, S. Bendahhou, P. Pierson, C. Sterner, J.

Peyronnet-Roux, C. Benfriha, I. Tegtmeier, H. Ehnes, M. Georgieff, F. Lesage, J. F. Brunet, C. Goridis, R. Warth and J.

Barhanin (2010). "Task2 potassium channels set central respiratory CO2 and O2 sensitivity." Proc Natl Acad Sci U S A

107(5): 2325-30.

Post Doc Cellulaire & Moleculaire, à Lyon, France

PHYSIOLOGIE INTEGRATIVE, CELLULAIRE ET MOLECULAIRE Unité Mixte de Recherche 5123 UMR 5123 CNRS /UCBL Bât. 8 Raphaël Dubois (ex. 404) – Campus La Doua 43, Bd du 11 novembre 1918 - 69622 VILLEURBANNE cedex Tél. : 04 72 43 10 32 ou 04 72 44 58 42 – fax : 04 72 43 11 72/04 72 44 79 37 physiologie@univ-lyon1.fr Directeur : Pr B. Allard

Université Lyon I

Appel d’offre d’allocation post-doctorale pour l’année 2010.

En 2010, l’Université Lyon I, propose une allocation de recherche pour l’accueil d’un(e) post-doctorant(e). L’allocation proposée est d’une durée de un an et pour un salaire brut annuel de 26 915 euros.

Titre du projet : Rôle des canaux TRP dans le déclenchement des crises d’hyperthermie maligne.

Contact ; personne ressource pour l’appel d’offre :

Pr. Fabien Van Coppenolle

UMR CNRS 5123

Physiologie Intégrative, Cellulaire et Moléculaire.

Université Claude Bernard Lyon I.

43 Bd du 11 Novembre 1918

Bât. Dubois

69 622 Villeurbanne Cédex

E-mail : Fabien.Van-coppenolle@adm.univ-lyon1.fr

Tel : 04 72 43 10 94

Pré-requis : techniques d’électrophysiologie (patch-clamp) et imagerie calcique.

Critères administratifs de sélection : les dossiers des candidats seront sélectionnés par un comité d’experts selon les critères suivants :

- Avoir obtenu son diplôme de doctorat depuis moins de cinq ans ;

- Avoir obtenu son doctorat dans un établissement d’enseignement supérieur extérieur au Pôle de Recherche et d’Enseignement de Lyon (PRES de Lyon) qui regroupe les établissements suivants : Université Lyon 1 ; Université Lyon 2 ; Université Lyon 3 ; Ecole Centrale de Lyon ; Ecole Normale Supérieure de Lyon ; Ecole Normale Supérieure de Lyon Lettres et Sciences Humaines ou sinon attester d’au moins 12 mois passés dans un laboratoire étranger ;

- Aucune condition restrictive de nationalité ou d’appartenance à la Communauté Européenne.

Dépôt des candidatures :

Les candidats doivent contacter la personne ressource indiquée ci-dessus. Les candidats doivent ensuite faire parvenir à la personne ressource le dossier de candidature.

La date limite de réception du dossier auprès de la personne ressource est le vendredi 18 juin 2010.

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PHYSIOLOGIE INTEGRATIVE, CELLULAIRE ET MOLECULAIRE Unité Mixte de Recherche 5123 UMR 5123 CNRS /UCBL Bât. 8 Raphaël Dubois (ex. 404) – Campus La Doua 43, Bd du 11 novembre 1918 - 69622 VILLEURBANNE cedex Tél. : 04 72 43 10 32 ou 04 72 44 58 42 – fax : 04 72 43 11 72/04 72 44 79 37 physiologie@univ-lyon1.fr Directeur : Pr B. Allard

Université Lyon I

Post doc recruitment session 2010.

Applicant’s selection

University Lyon 1 offers a post doctoral position for 2010 aimed at young researchers from France and abroad to enable them to acquire high level research experience. The post doc is a salary position of 26 915 euros.

Title of the project: Role of TRP channels in malignant hyperthermia.

Contact ; Resource person for application:

Pr. Fabien Van Coppenolle

UMR CNRS 5123

Physiologie Intégrative, Cellulaire et Moléculaire.

Université Claude Bernard Lyon I.

43 Bd du 11 Novembre 1918

Bât. Dubois

69 622 Villeurbanne Cédex

E-mail : Fabien.Van-coppenolle@adm.univ-lyon1.fr

Tel : 04 72 43 10 94

Skills: Patch-clamp and calcium imaging.

Criteria: the ad hoc committee will select the applicants with the following criteria.

Applicants must:

- Have a Ph D degree for no more than 5 years ;

- Have a Ph D degree from an institution outside of PRES of Lyon (University Lyon 1 ; Lyon 2 ; Lyon 3 ; ECL ; ENS ; ENS LSH) or justify from a post doctoral position research experience abroad of at least 1 year.

- There is no nationality restrictions.

Application form:

Applicants must contact Pr. Van Coppenolle and send him a complete application form.

Applications must be received by June 18th, 2010.

Post-Doc in Biochemistry or Biological Sciences in Dijon, France

The INSERM U866 Research Centre “Lipids, Nutrition, Cancer”

has an open position for

a Post-Doc

(PhD in Biochemistry or Biological Sciences)

For a transversal project in the INSERM Research Centre to improve the outcome

of cancer therapy by testing new potential treatments against human tumors (colon,

and breast cancer) with high level of efficacy and low toxicity.

Despite aggressive therapies, resistance of many tumors to established treatment

procedures still constitutes a major problem in cancer therapy. For example, the

therapeutic strategy of colorectal cancer is mainly based on surgery and a palliative

chemotherapy with 5-FU/folinic acid associated with Irinotecan.

However this strategy is not very successful, mainly due to establishment of a strong

resistance of cancer cells against the cytotoxic drugs, and to metastatic invasion.

The overall aim of the proposed transversal project in the INSERM U866 Unit “Lipids,

Nutrition, Cancer” is to evaluate: 1) the effect of polyphenols and new chemicals

analogues on the tumor cell plasma membrane, 2) and to determine novel cellular targets

in the cellular lipid metabolism which is implicated in the chemotherapeutic response and

in the Multi-Drug Resistance.

Disciplines: Biochemistry, Cellular and Molecular Biology

This project is part of a large scale program involving several teams in the INSERM Unit

Beside basis support from INSERM and French Ministery of research, this program is

supported by the “Conseil Régional de Bourgogne”, the vitivinicultural sector, the NACre

(Nutrition-Food Cancer research) network, the “Cancer League” (Côte d'Or committee) and

INCa (National Cancer Institute and Easter France Cancer cluster).

This position will be available in September-October 2010

and offers a competitive salary (2,500 euros per month).

General information on the INSERM U866 Research Center is available at:

http://www.u-bourgogne.fr/INSERM-U866/indexe.html

The INSERM Research Centre is situated in the University of Dijon, near the University

Hospital, with excellent communication facilities. Language spoken include English and

French. The INSERM Unit counts 10 teams with about 220 people and supported by 11

technical platforms (Cytometry, lipidomics, proteomics, metabolomics, RPE, …) in the

Research Federative Institute “Santé-Stic” (http://www.u-bourgogne.fr/IFR100/)

Curriculum vitae, name and contact details of two referees have to be sent to the

Supervisor of the Research Program by Email to

Dr. DELMAS Dominique (ddelmas@u-bourgogne.fr)

INSERM Research Center “Lipids, Nutrition, Cancer”

Team 9 “Metabolic and Nutritional Laboratory”

University of Burgundy, Faculty of Sciences, 6 Bd Gabriel 21000 Dijon – FRANCE

Tel: +33 3 80 39 37 01

PhD position in Nice, France

REGULATION OF ION CHANNELS IN CARCINOGENESIS

PhD position (CNRS/PACA funding) available from September 2010 in the Institute of

Developmental Biology and Cancer (UNSA CNRS UMR 6543), in the group of Dr Franck

Borgese at the University of Nice Sophia Antipolis / CNRS, Nice, France.

Thesis supervisor: Dr Olivier Soriani

Our project will focus on the regulation of ion channels involved in cancer cell behaviour

(apoptosis resistance, extra cellular matrix adhesion and degradation, motility, proliferation).

Recently, we have demonstrated that a unique tumour biomarker, the sigma-1 receptor

(Sig1R), was functionally associated to Cl- and K+ channels in lung cancer and leukaemia

cells. We have shown that the over-expression of Sig1R in cancer cells enhances cell

apoptotic resistance through a decrease of volume-regulated Cl- channels activation kinetics

(Renaudo et al., 2007; Le Guennec et al., 2008). Moreover, exogenous sigma ligands inhibit

cell cycle through a K+ channel / p27kip1-dependent pathway (Renaudo et al. 2004).

The project will deal on the molecular mechanisms associating the Sig1R to ion channels

aberrantly expressed in leukaemia and breast cancer cells, in relation to their

aggressiveness state. Finally, in vivo significance of the described mechanisms will be

explored in a mouse metastatic model.

Main technical approaches: Molecular cell biology, genetics, microscopy imagery and

electrophysiology (patch-clamp).

We are seeking highly talented and self-motivated candidates. A background in the field of

electrophysiology and cell physiology will be appreciated. The position will be available on

September 2010.

Candidates are invited to obtain application forms from soriani@unice.fr or borgese@unice.fr

Application deadline: Friday 30th April.

Provisional date for auditions of short listed candidates: Monday 17th May

Références:

· Martial,S., Giorgelli,J.L., Renaudo,A., Derijard,B., and Soriani,O. (2008). SP600125 inhibits Kv

channels through a JNK-independent pathway in cancer cells. Biochem. Biophys. Res.

Commun. 366, 944-950

· Renaudo,A., L'Hoste,S., Guizouarn,H., Borgese,F., and Soriani,O. (2007). Cancer cell cycle

modulated by a functional coupling between sigma receptors and Cl- channels. J. Biol. Chem.

282, 2259-2267.

· Le Guennec,J.Y., Ouadid-Ahidouch,H., Soriani,O., Besson,P., Ahidouch,A., and Vandier,C.

(2007). Voltage-gated ion channels, new targets in anti-cancer research. Recent Patents

Anticancer Drug Discov. 2, 189-202.

· Renaudo,A., Watry,V., Chassot,A.A., Ponzio,G., Ehrenfeld,J., and Soriani,O. (2004). Inhibition

of tumor cell proliferation by sigma ligands is associated with K+ Channel inhibition and

p27kip1 accumulation. J. Pharmacol. Exp. Ther. 311, 1105-1114.